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1996-03-09
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Document 0142
DOCN M9650142
TI [Bilateral acute retinal necrosis in a patient with acquired
immunodeficiency syndrome]
DT 9605
AU Menerath JM; Gerard M; Laurichesse H; Goldschmidt P; Peigue-Lafeuille H;
Rozenberg F; Beytout J; Service d'Ophtalmologie, Hopital Gabriel
Montpied, CHU, BP 69,; Clermont-Ferrand.
SO J Fr Ophtalmol. 1995;18(10):625-33. Unique Identifier : AIDSLINE
MED/96146818
AB A case of bilateral progressive outer retinal necrosis occurred after
herpes zoster ophthalmicus in a patient with acquired immunodeficiency
syndrome. This case does not correspond to the classical picture of
progressive outer retinal necrosis. The disease led to blindness despite
intravenous therapy with acyclovir and foscarnet. PCR could not identify
any virus in the aqueous humour, but VZV is evidenced in cerebrospinal
fluid. Acute retinal necrosis is now clearly defined by the American
Uveitis Society, which should allow to determine its incidence and risk
factors. Herpes zoster usually precedes the acute outer retinal
necrosis. The infectious theory (VZV, HSV, CMV) widely prevails over the
immune theory. We prefer the virus genome identification in the aqueous
humor or in the vitreous by PCR to confirm diagnosis rather than the
specific antibody titration. Therapy consists in acyclovir, foscarnet
and ganciclovir. But whatever the treatment, the visual prognosis is
poor.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/THERAPY Antiviral
Agents/THERAPEUTIC USE Case Report English Abstract Herpes Zoster
Ophthalmicus/ETIOLOGY/PHYSIOPATHOLOGY/THERAPY Human Male Middle Age
Retinal Necrosis Syndrome, Acute/*ETIOLOGY/PHYSIOPATHOLOGY/ THERAPY
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).